The relationship between force and focal complex development

@article{Galbraith2002TheRB,
  title={The relationship between force and focal complex development},
  author={Catherine G Galbraith and Kenneth M Yamada and Michael P Sheetz},
  journal={The Journal of Cell Biology},
  year={2002},
  volume={159},
  pages={695 - 705}
}
To adhere and migrate, cells must be capable of applying cytoskeletal force to the extracellular matrix (ECM) through integrin receptors. However, it is unclear if connections between integrins and the ECM are immediately capable of transducing cytoskeletal contraction into migration force, or whether engagement of force transmission requires maturation of the adhesion. Here, we show that initial integrin-ECM adhesions become capable of exerting migration force with the recruitment of vinculin… CONTINUE READING
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