The relationship between evolutionary and physiological variation in hemoglobin.

@article{Milo2007TheRB,
  title={The relationship between evolutionary and physiological variation in hemoglobin.},
  author={Ron Milo and Jennifer H. Hou and Michael Springer and Michael P. Brenner and Marc W Kirschner},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2007},
  volume={104 43},
  pages={
          16998-7003
        }
}
Physiological and evolutionary adaptations operate at very different time scales. Nevertheless, there are reasons to believe there should be a strong relationship between the two, as together they modify the phenotype. Physiological adaptations change phenotype by altering certain microscopic parameters; evolutionary adaptation can either alter genetically these same parameters or others to achieve distinct or similar ends. Although qualitative discussions of this relationship abound, there has… CONTINUE READING
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