The relationship between depression and interferon beta-1a therapy in patients with multiple sclerosis.

@article{Patten2005TheRB,
  title={The relationship between depression and interferon beta-1a therapy in patients with multiple sclerosis.},
  author={Scott B Patten and Gordon Francis and Luanne M. Metz and Maria Lopez-Bresnahan and Peter Chang and François Curtin},
  journal={Multiple sclerosis},
  year={2005},
  volume={11 2},
  pages={175-81}
}
It has been suggested that interferons (IFN) may cause depression de novo or worsen pre-existing depression. Depression data collected using validated instruments from individual clinical trials in multiple sclerosis, however, have consistently failed to identify an association. In this study, pooled data from 6 controlled studies and 17 noncontrolled clinical trials of subcutaneous IFN beta-1a were assessed to determine the relationship between IFN therapy with physician reports of depression… CONTINUE READING