The relationship between cyclooxygenase-2 expression and colorectal cancer.

@article{Sheehan1999TheRB,
  title={The relationship between cyclooxygenase-2 expression and colorectal cancer.},
  author={Katherine M. Sheehan and Kieran Sheahan and Diarmuid P. O'Donoghue and Fergus Macsweeney and Ronan M Conroy and Desmond J. Fitzgerald and Frank E. Murray},
  journal={JAMA},
  year={1999},
  volume={282 13},
  pages={1254-7}
}
CONTEXT Epidemiological studies have implicated the inducible form of cyclooxygenase (COX-2) in the pathogenesis of colorectal cancer; however, its role is not fully understood. OBJECTIVE To examine the relationship between the expression of COX-2 in human colorectal cancer and patient survival. DESIGN Patients diagnosed as having colorectal cancer were evaluated and followed up for up to 9.4 years (median follow-up, 2.7 years). Tumor sections were stained for COX-2 using a rabbit… CONTINUE READING