The relationship between bone, hemopoietic stem cells, and vasculature.

@article{Ellis2011TheRB,
  title={The relationship between bone, hemopoietic stem cells, and vasculature.},
  author={Sarah L. Ellis and Jochen Grassinger and Allan Jones and Judy Borg and Todd D. Camenisch and David N. Haylock and Ivan Bertoncello and Susan K Nilsson},
  journal={Blood},
  year={2011},
  volume={118 6},
  pages={1516-24}
}
A large body of evidence suggests hemopoietic stem cells (HSCs) exist in an endosteal niche close to bone, whereas others suggest that the HSC niche is intimately associated with vasculature. In this study, we show that transplanted hemopoietic stem and progenitor cells (HSPCs) home preferentially to the trabecular-rich metaphysis of the femurs in nonablated mice at all time points from 15 minutes to 15 hours after transplantation. Within this region, they exist in an endosteal niche in close… CONTINUE READING

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Induction of the chemokine stromal-derived factor-1 following RELATIONSHIP BETWEEN HSC, BONE, AND VASCULATURE

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