The relationship between antidepressant prescription rates and rate of early adolescent suicide.

@article{Gibbons2006TheRB,
  title={The relationship between antidepressant prescription rates and rate of early adolescent suicide.},
  author={Robert D. Gibbons and Kwan Hur and Dulal K. Bhaumik and J. John Mann},
  journal={The American journal of psychiatry},
  year={2006},
  volume={163 11},
  pages={
          1898-904
        }
}
OBJECTIVE In 2002, 264 children and adolescents ages 5-14 died by suicide in the United States, the fifth leading cause of death. Of these suicides, 260 were in the 10-14 year age group, making suicide the third largest cause of death behind accidents and malignancy. Although 60% of suicides in the general population occur in the midst of a mood disorder, usually untreated, little is known about the relationship between treatment of mood disorders and youth suicide. The FDA recently linked… Expand

Paper Mentions

Early evidence on the effects of regulators' suicidality warnings on SSRI prescriptions and suicide in children and adolescents.
TLDR
In both the United States and the Netherlands, SSRI prescriptions for children and adolescents decreased after U.S. and European regulatory agencies issued warnings about a possible suicide risk with antidepressant use in pediatric patients, and these decreases were associated with increases in suicide rates inChildren and adolescents. Expand
An update on antidepressant use and suicidality in pediatric depression
TLDR
This review provides an overview of the temporal associations of regulatory agencies' actions in North America and Europe with rates of depression diagnoses, pediatric antidepressant prescription rates, follow-up visits to physicians prescribing antidepressants, and rates of completed suicide and suicidal ideation in children and adolescents. Expand
Antidepressants in adult suicides in New York City: 2001-2004.
TLDR
This study does not provide evidence for a link between antidepressant use and subsequent suicide, but careful monitoring of patients receiving antidepressants remains critically important. Expand
Antidepressant Drugs and the Risk of Suicide in Children and Adolescents
TLDR
It is concluded that the decisions for the ‘black box’ warnings were based on biased data and invalid assumptions and were unsupported by the observational data regarding suicide in young people that existed in 2003. Expand
Ecological Studies of Antidepressant Treatment and Suicidal Risks
TLDR
Overall, these findings yield limited and inconsistent support for the hypothesis that increased use of modern antidepressants might limit suicide risk, and no evidence that the risk increased. Expand
Successful Suicide in a Child: Depression-Related or Paroxetine-Induced?
Background : Children and adolescents are prone to develop psychiatric problems after stressful life events. These problems need appropriate treatment because of negative consequences likeExpand
Season of treatment initiation with antidepressants and suicidal behavior: A population-based cohort study in Sweden.
TLDR
The results indicate an interaction between biological and health care-related factors for the observed seasonal pattern of suicidal behavior in the elderly, whereas psychological and societal factors may be more important for the seasonality observed in the younger patients. Expand
Antidepressants and Suicide Risk: Considerations in Treating Patients with Major Depression
TLDR
Evidence concerning antidepressants and suicidality is reviewed, the FDA’s warnings and their impact on patient care are discussed, and recommendations for managing patients with depression in light of the warnings are made. Expand
Suicide in Children
TLDR
This chapter will address the terminology used to discuss suicide, the epidemiology of youth suicide, risk and protective factors, and approaches to screening for suicide and conducting follow-up assessments for at-risk youth. Expand
The Treatment of Suicide and Self-Injurious Behaviors in Children and Adolescents
Purpose Suicide is currently the second leading cause of death for 10–34 year-olds. Moreover, up to 20% of adolescents report engaging in non-suicidal self-injury (NSSI) at some point in theirExpand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 88 REFERENCES
The relationship between antidepressant medication use and rate of suicide.
TLDR
Increases in prescriptions for SSRIs and other new-generation non-SSRIs are associated with lower suicide rates both between and within counties over time and may reflect antidepressant efficacy, compliance, a better quality of mental health care, and low toxicity in the event of a suicide attempt by overdose. Expand
Relationship between antidepressant medication treatment and suicide in adolescents.
TLDR
An inverse relationship between regional change in use of antidepressants and suicide raises the possibility of a role for using antidepressant treatment in youth suicide prevention efforts, especially for males, older adolescents, and adolescents who reside in lower-income regions. Expand
Antidepressants and suicide risk in the United States, 1985-1999.
TLDR
The decline in the national suicide rate appears to be associated with greater use of non-tricyclic antidepressants, and treatment of a greater proportion of mood disorders with SSRIs and other second-generation non- TCA antidepressants may further reduce the suicide rate. Expand
Evaluation of suicidal thoughts and behaviors in children and adolescents taking paroxetine.
TLDR
The presence of uncontrolled suicide risk factors, the relatively low incidence of these events, and their predominance in adolescents with MDD make it difficult to identify a single cause for suicidality in these pediatric patients. Expand
Antidepressant Treatment and Risk of Suicide Attempt by Adolescents with Major Depressive Disorder
TLDR
Antidepressant medication use had no statistically significant effect on the likelihood of suicide attempt in a large cohort of adolescents across the US after propensity adjustment for treatment allocation and controlling for other factors. Expand
Suicide and the use of antidepressants Drug treatment of depression is inadequate
EDITOR, - Goran Isacsson and colleagues suggest that therapeutic failure of antidepressant drugs may be a greater problem in people who commit suicide than toxicity in overdose as their resultsExpand
Paroxetine, other antidepressants, and youth suicide in New York City: 1993 through 1998.
TLDR
Despite regulatory concerns, none of the autopsies of youth suicides in New York City detected paroxetine in the victims, although other antidepressants were detected in 4 victims. Expand
Do antidepressants prevent suicide?
TLDR
Investigating the relationship between treatment with antidepressants and suicide on individualized data from a nationwide study with linkage of registers of all prescribed antidepressants and recorded suicides in Denmark finds continued antidepressant treatment with SSRIs or other newer antidepressants is found to be associated with a reduced risk of suicide. Expand
Childhood depression and risk of suicide: a preliminary report of a longitudinal study.
TLDR
It is suggested that major depressive disorder in childhood has significant mortality by suicide and at least five of the seven subjects had recurrent depressive symptoms and were clinically depressed at the time of death. Expand
Suicide risk during antidepressant treatment.
TLDR
The authors used population-based data to evaluate the risk of suicide death and serious suicide attempt in relation to initiation of antidepressant treatment and found a significant increase in risk of suicidal activity after starting treatment with newer antidepressant drugs is not indicated. Expand
...
1
2
3
4
5
...