The relationship between alcoholic cerebellar degeneration and cognitive and emotional functioning

@article{Fitzpatrick2008TheRB,
  title={The relationship between alcoholic cerebellar degeneration and cognitive and emotional functioning},
  author={Lauren E Fitzpatrick and M. Jackson and Simon F. Crowe},
  journal={Neuroscience \& Biobehavioral Reviews},
  year={2008},
  volume={32},
  pages={466-485}
}
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The results suggest that some of the cognitive and affective deficits observed in chronic alcoholics may be mediated, at least in part, by cerebellar dysfunction, and add support to the theory of disruption to bidirectional cerebro-cerebellar circuitry underlying cognitive and affectsive deficits in Chronic alcoholics.
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The role of the human cerebellum in different features of emotions is supported and different thalamic nuclei influence the cerebellar motor and cognitive functions and its role in the modulation of emotion is demonstrated.
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Alcohol-related neurocognitive dysfunction is described more extensively in the DSM-5 than it was in theDSM-IV-TR, with an essential role for neuropsychological assessment for the classification, diagnosis, and treatment of neuro cognitive deficits.
Characterization of cerebellar ataxia in chronic alcoholics using the International Cooperative Ataxia Rating Scale (ICARS).
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Age, gender, and the source of the clinical sample may significantly contribute to the prevalence of ACD and require further detailed investigation.
Brain Atrophy in Alcoholics
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Although pathogenesis is still obscure, cytokine-mediated neuroinflammation and oxidative damage play a role in brain atrophy of uncomplicated alcoholics, and several reports also suggest that patients with chronic liver disease also present neurocognitive impairment independent of alcohol intake.
Modulation of limbic-cerebellar functional connectivity enables alcoholics to recognize who is who
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FMRI analysis indicated that alcoholics had preserved limbic activation but lower cerebellar activation than the controls in the face–name learning task, and it is speculated that atypical cerebello-hippocampal activity synchronization during rest in alcoholics was reset to the normal pattern of asynchrony by task engagement.
Empathy and social problem solving in alcohol dependence, mood disorders and selected personality disorders
Posterior cerebellar vermal deficits in bipolar disorder.
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