The relationship between alcoholic cerebellar degeneration and cognitive and emotional functioning

  title={The relationship between alcoholic cerebellar degeneration and cognitive and emotional functioning},
  author={Lauren E Fitzpatrick and M. Jackson and Simon F. Crowe},
  journal={Neuroscience \& Biobehavioral Reviews},
Cognitive and Emotional Deficits in Chronic Alcoholics: a Role for the Cerebellum?
The results suggest that some of the cognitive and affective deficits observed in chronic alcoholics may be mediated, at least in part, by cerebellar dysfunction, and add support to the theory of disruption to bidirectional cerebro-cerebellar circuitry underlying cognitive and affectsive deficits in Chronic alcoholics.
The Neglected Cerebello-Limbic Pathways and Neuropsychological Features of the Cerebellum in Emotion
The role of the human cerebellum in different features of emotions is supported and different thalamic nuclei influence the cerebellar motor and cognitive functions and its role in the modulation of emotion is demonstrated.
The neuropsychology of alcohol use disorder: A multimethod evaluation of cognition and illness insight
Alcohol-related neurocognitive dysfunction is described more extensively in the DSM-5 than it was in theDSM-IV-TR, with an essential role for neuropsychological assessment for the classification, diagnosis, and treatment of neuro cognitive deficits.
Characterization of cerebellar ataxia in chronic alcoholics using the International Cooperative Ataxia Rating Scale (ICARS).
Age, gender, and the source of the clinical sample may significantly contribute to the prevalence of ACD and require further detailed investigation.
Brain Atrophy in Alcoholics
Although pathogenesis is still obscure, cytokine-mediated neuroinflammation and oxidative damage play a role in brain atrophy of uncomplicated alcoholics, and several reports also suggest that patients with chronic liver disease also present neurocognitive impairment independent of alcohol intake.
Modulation of limbic-cerebellar functional connectivity enables alcoholics to recognize who is who
FMRI analysis indicated that alcoholics had preserved limbic activation but lower cerebellar activation than the controls in the face–name learning task, and it is speculated that atypical cerebello-hippocampal activity synchronization during rest in alcoholics was reset to the normal pattern of asynchrony by task engagement.
Posterior cerebellar vermal deficits in bipolar disorder.


The cerebellar cognitive affective syndrome.
A constellation of deficits is suggestive of disruption of the Cerebellar modulation of neural circuits that link prefrontal, posterior parietal, superior temporal and limbic cortices with the cerebellum, called the 'cerebellar cognitive affective syndrome'.
Psychiatric syndromes in cerebellar degeneration
The demonstration that psychiatric disorders may be the consequence of degenerative diseases affecting the cerebellum provides an insight into the neuroanatomical basis for psychopathology, and provides further validation of the general concept that many psychiatric syndromes are rooted in the brain.
Disorders of the cerebellum: ataxia, dysmetria of thought, and the cerebellar cognitive affective syndrome.
  • J. Schmahmann
  • Psychology, Biology
    The Journal of neuropsychiatry and clinical neurosciences
  • 2004
The cerebellar cognitive affective syndrome (CCAS) includes impairments in executive, visual-spatial, and linguistic abilities, with affective disturbance ranging from emotional blunting and depression, to disinhibition and psychotic features.
Pattern of motor and cognitive deficits in detoxified alcoholic men.
Compared with controls, the alcoholics were impaired on executive functions, visuospatial abilities, and gait and balance even after the authors accounted for group differences in estimated premorbid IQ and education.
Emotion control and cerebellar atrophy in senile dementia.
Patterns of cognitive impairment among alcoholics: are there subtypes?
Findings indicate that empirical support for the mild generalized dysfunction hypothesis of alcoholics' cognitive deficits is not an artifact of averaging.
Contributions of age and alcohol consumption to cerebellar integrity, gait and cognition in non-demented very old individuals
The results indicate that the cerebellum may be susceptible to alcohol-related shrinkage in non-demented very old individuals, more so in men, even at low dose.