The relationship between adrogen receptors and the hormonally controlled responses of rat ventral prostate.

@article{Doorn1976TheRB,
  title={The relationship between adrogen receptors and the hormonally controlled responses of rat ventral prostate.},
  author={E van Doorn and Stephen A. Craven and Nicholas Bruchovsky},
  journal={The Biochemical journal},
  year={1976},
  volume={160 1},
  pages={
          11-21
        }
}
1. The administration of dihydrotestosterone to rats orchidectomized 7 days previously stimulated the synthesis of nuclear receptor in prostatic cells several hours in advance of DNA synthesis and mitosis. 2. The synthesis of nuclear receptor is tightly coupled to cell proliferation; consequently, in resting cells, there is no further net synthesis of nuclear receptor above the maximum of approx. 8000 molecules/cell. 3. After orchidectomy a rapid decline in the concentration of free androgen in… CONTINUE READING