The relationship between accumulation of advanced glycation end products and expression of vascular endothelial growth factor in human diabetic retinas

@article{Murata1997TheRB,
  title={The relationship between accumulation of advanced glycation end products and expression of vascular endothelial growth factor in human diabetic retinas},
  author={Toshinori Murata and Ryozo Nagai and T Ishibashi and Hajime Inomata and Kazuhito Ikeda and Seikoh Horiuchi},
  journal={Diabetologia},
  year={1997},
  volume={40},
  pages={764-769}
}
Both advanced glycation end products and vascular endothelial growth factor are believed to play a role in the pathogenesis of diabetic retinopathy. It is known that vascular endothelial growth factor causes retinal neovascularization and a breakdown of the blood-retinal barrier; how advanced glycation end products affect the retina, however, remains largely unclear. The substance Ne-(carboxymethyl)lysine is a major immunologic epitope, i. e. a dominant advanced glycation end products antigen… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 63 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 41 references

Advanced glycation end products (AGE) increase retinal VEGF gene expression

  • AP Adamis, M Kuroki, MJ Tolentino, I Kim
  • Invest Ophthalmol Vis Sci
  • 1996
3 Excerpts

Similar Papers

Loading similar papers…