The relationship between NSAID use and osteoarthritis (OA) severity in patients with hip and knee OA: results of a case control study of NSAID use comparing those requiring hip and knee replacements to those in whom surgery was not recommended.

@article{Pope2008TheRB,
  title={The relationship between NSAID use and osteoarthritis (OA) severity in patients with hip and knee OA: results of a case control study of NSAID use comparing those requiring hip and knee replacements to those in whom surgery was not recommended.},
  author={Janet E Pope and Kelly McCrea and Adam Stevens and Janine M. Ouimet},
  journal={Medical science monitor : international medical journal of experimental and clinical research},
  year={2008},
  volume={14 12},
  pages={
          CR604-10
        }
}
BACKGROUND NSAIDs are not considered disease modifying in osteoarthritis (OA), though there has been debate that some may be chondroprotective and others chondrodestructive. We performed a case control study comparing NSAID use in subjects with hip or knee OA who had been treated surgically vs. medically. The purpose was to determine the relationship between NSAIDs and OA severity and if NSAIDs had a chondroprotective or chondrodestructive effect in our cohort. MATERIAL/METHODS The study… CONTINUE READING