The relationship between CD86/CD54 expression and THP-1 cell viability in an in vitro skin sensitization test – human cell line activation test (h-CLAT)

@article{Sakaguchi2008TheRB,
  title={The relationship between CD86/CD54 expression and THP-1 cell viability in an in vitro skin sensitization test – human cell line activation test (h-CLAT)},
  author={Hitoshi Sakaguchi and Takao Ashikaga and Masaaki Miyazawa and Nanae Kosaka and Yuichi Ito and Katsurako Yoneyama and Sakiko Sono and Hiroshi Itagaki and Hidekazu Toyoda and Hiroyuki Suzuki},
  journal={Cell Biology and Toxicology},
  year={2008},
  volume={25},
  pages={109-126}
}
Recent regulations for cosmetics in Europe prohibit animal testing for evaluating the sensitization potential of chemicals to improve animal welfare. Yet, there is not an acceptable Organization for Economic Co-operation and Development non-animal skin sensitization test method. Several in vitro skin sensitization methods that focus on the activation of Langerhans cells, including human cell lines, are being evaluated as possible alternatives. In our previous study, we optimized our human cell… CONTINUE READING

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