The relations between ionic and non-ionic diffusion of sulfonamides across the rabbit cornea.

@article{Jankowska1986TheRB,
  title={The relations between ionic and non-ionic diffusion of sulfonamides across the rabbit cornea.},
  author={L M Jankowska and Amir Bar-Ilan and Thomas H. Maren},
  journal={Investigative ophthalmology & visual science},
  year={1986},
  volume={27 1},
  pages={29-37}
}
We studied the transcorneal permeability of five carbonic anhydrase inhibitors, with particular attention to the passage of these acidic compounds in their ionized and nonionized forms. Their pKs varied from 5.9 to 8.0, and CHCl3/pH 7.2 buffer partition coefficients from 10(-4) to 25. Solutions of appropriate pH of each compound were applied to the cornea in steady state, and the rates of passage to the anterior chamber for each compound in each form were measured. The rate constants for the… CONTINUE READING

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