The relation of p53 gene mutations to gastric cancer subsite and phenotype

  title={The relation of p53 gene mutations to gastric cancer subsite and phenotype},
  author={Dawn Tolbert and Cecilia Fenoglio-Preiser and Amy Noffsinger and G. De Voe and Jack MacDonald and Jacqueline Benedetti and Grant N. Stemmermann},
  journal={Cancer Causes & Control},
Objectives: We investigated p53 gene mutations in advanced gastric cancers by direct DNA sequencing, in order to determine the frequency of mutations in gastric cancers having different epidemiological backgrounds, tumors of the cardia were compared with those arising in the antrum or corpus. Intestinal type cancers were compared with diffuse or other histologic types. We have chosen to assess the frequency of mutations solely based on DNA sequencing. Methods: Paraffin embedded tissues from 100… CONTINUE READING


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Publications referenced by this paper.
Showing 1-10 of 33 references

p53 immunoreactivity and single-strand conformational polymorphism analysis often fail to predict p53 mutational status.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc • 1999
View 1 Excerpt

Use of aspirin and other nonsteroidal anti-inflammatory drugs and risk of esophageal and gastric cancer.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology • 1998
View 1 Excerpt

Adenocarcinoma of the esophagus and gastric cardia: Medical conditions, tobacco, alcohol and socioeconomic factors

Z-F Zhang, RC Kurtz, +5 authors S Harlap
Cancer Epidemiol Biomarkers Prev • 1996

Intestinal and di€use gastric cancers arise on a di€erent background of Helicobacter pylori gastritis through di€erent gene involvement

E Solcia, R Fiocca, +6 authors C Capella
Am J Surg Path • 1996

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