The relation of central 5-HT1A and 5-HT2 receptors: low dose agonist-induced selective tolerance in the rat.

@article{Pranzatelli1991TheRO,
  title={The relation of central 5-HT1A and 5-HT2 receptors: low dose agonist-induced selective tolerance in the rat.},
  author={Michael R Pranzatelli and R S Pluchino},
  journal={Pharmacology, biochemistry, and behavior},
  year={1991},
  volume={39 2},
  pages={407-13}
}
To study the purported relation of 5-HT1A and 5-HT2 receptors, we chronically injected rats with a low dose of selective 5-HT agonists to induce behavioral tolerance and then tested for cross-tolerance. Acutely, in naive rats, both the putative 5-HT2 agonist DOI and 5-HT1A agonist 8-OH-DPAT induced some behaviors of the "serotonin syndrome" but the two drugs could be differentiated. Only DOI evoked shaking behavior, "skin jerks" (spinal myoclonus), and hyperthermia. Only 8-OH-DPAT induced flat… CONTINUE READING

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