The relation of SF3B1 mutation and intracellular iron in myelodysplastic syndrome with less than 5% bone marrow blasts.

@article{Ma2019TheRO,
  title={The relation of SF3B1 mutation and intracellular iron in myelodysplastic syndrome with less than 5% bone marrow blasts.},
  author={Liya Ma and Yingwan Luo and Lingxu Jiang and Dan Dan Shen and Jianhu Li and Weilai Xu and Chen Mei and Xinping Zhou and Yanlin Ren and Li Ye and Chenxi Lu and Jin Chuan Jie and Hongyan Tong},
  journal={Leukemia & lymphoma},
  year={2019},
  volume={60 5},
  pages={
          1179-1186
        }
}
According to 2008 WHO classification RARS is regarded as less than 5% blasts and more than 15% ring sideroblasts in the bone marrow. In 2016 WHO classification MDS-RS is revised as more than 15% ring sideroblasts or more than 5% ring sideroblasts in the presence of the SF3B1 mutation. In our study, we classified intracellular iron in bone marrow into four types according to the size and quantity of iron granules. We found that there was a significant difference between SF3B1-mutant and SF3B1… CONTINUE READING