The relation of RNA and protein synthesis to the sedimentation of muscle ribosomes: effect of diabetes and insulin.

@article{Stirewalt1967TheRO,
  title={The relation of RNA and protein synthesis to the sedimentation of muscle ribosomes: effect of diabetes and insulin.},
  author={William S. Stirewalt and Ira G. Wool and Phyllis Cavicchi},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1967},
  volume={57 6},
  pages={
          1885-92
        }
}
Ribosomes from muscle of alloxan-diabetic rats function less efficiently in the synthesis of protein than ribosomes from normal animals.1-4 The nature of the change in function is unknown. The decrease in protein synthesis is not due to a deficiency in the amount of messenger RNA, but rather the result of a defect in its utilization or translation by ribosomes." 2 An important unresolved problem is the nature of the putative change in the ribosomes that leads to an alteration in the translation… CONTINUE READING