The relation between membrane potential, membrane currents and activation of contraction in ventricular myocardial fibres.

@article{Beeler1970TheRB,
  title={The relation between membrane potential, membrane currents and activation of contraction in ventricular myocardial fibres.},
  author={G W Beeler and Harald Reuter},
  journal={The Journal of physiology},
  year={1970},
  volume={207 1},
  pages={211-29}
}
1. Membrane currents and contractile responses have been measured in ventricular myocardial preparations under voltage clamp conditions.2. In Tyrode solution, steady-state contraction was obtained only after 5-8 depolarizations to a given potential level. The threshold of steady-state tension was identical to the potential where the calcium inward current, I(Ca), was activated (about -35 mV). Both thresholds were shifted in the same direction along the voltage axis and by the same amount by… CONTINUE READING