The relation between depression and parkin genotype: the CORE-PD study.

  title={The relation between depression and parkin genotype: the CORE-PD study.},
  author={Abhishek K. Srivastava and Meng-Xing Tang and Helen Mejia-Santana and Llency Rosado and Elan Daniel Louis and Elise Caccappolo and Cynthia Comella and Amy Colcher and Andrew D. Siderowf and Danna Jennings and M Susan Nance and Susan S Bressman and William K. Scott and Caroline Tanner and Susan F Mickel and H. C. Andrews and Cheryl H. Waters and Stanley Fahn and Lucien Cote and Steven Frucht and Blair Ford and Roy N Alcalay and Barbara Ross and Martha Orbe Reilly and Michael Rezak and Kevin E Novak and Joseph H Friedman and Rhonda Pfeiffer and Laur Marsh and Brad Hiner and Dominike Merle and Ruth Ottman and Lorraine N. Clark and Karen S. Marder},
  journal={Parkinsonism & related disorders},
  volume={17 10},
BACKGROUND Mutations in parkin are a known genetic risk factor for early onset Parkinson's disease (EOPD) but their role in non-motor manifestations is not well established. Genetic factors for depression are similarly not well characterized. We investigate the role of parkin mutations in depression among those with EOPD and their relatives. METHODS We collected psychiatric information using the Patient Health Questionnaire and Beck Depression Inventory II on 328 genotyped individuals… CONTINUE READING

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