• Corpus ID: 10519594

The relation between alignment covariance and background-averaged epistasis

  title={The relation between alignment covariance and background-averaged epistasis},
  author={Frank J. Poelwijk and Rama Ranganathan},
  journal={arXiv: Quantitative Methods},
Epistasis, or the context-dependence of the effects of mutations, limits our ability to predict the functional impact of combinations of mutations, and ultimately our ability to predict evolutionary trajectories. Information about the context-dependence of mutations can essentially be obtained in two ways: First, by experimental measurement the functional effects of combinations of mutations and calculating the epistatic contributions directly, and second, by statistical analysis of the… 

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