The reinforcing properties of salsolinol in the ventral tegmental area: evidence for regional heterogeneity and the involvement of serotonin and dopamine.

@article{Rodd2008TheRP,
  title={The reinforcing properties of salsolinol in the ventral tegmental area: evidence for regional heterogeneity and the involvement of serotonin and dopamine.},
  author={Zachary A. Rodd and Scott M. Oster and Zheng-Ming Ding and Jamie E. Toalston and Gerald A Deehan and Richard L. Bell and T K Li and William J H Mcbride},
  journal={Alcoholism, clinical and experimental research},
  year={2008},
  volume={32 2},
  pages={230-9}
}
BACKGROUND Salsolinol (SAL), the condensation product of acetaldehyde and dopamine, may be a factor contributing to alcohol abuse. Previous research indicated that both ethanol and acetaldehyde are self-administered into the posterior ventral tegmental area (VTA). The current study examined SAL self-infusions into the VTA, and determined the involvement of dopamine neurons and 5-HT3 receptors in this process. METHODS The intracranial self-administration technique was used to determine the… CONTINUE READING

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