The reinforcing efficacy of psychostimulants in rhesus monkeys: the role of pharmacokinetics and pharmacodynamics.

@article{Lile2003TheRE,
  title={The reinforcing efficacy of psychostimulants in rhesus monkeys: the role of pharmacokinetics and pharmacodynamics.},
  author={Joshua A. Lile and Zhixia Wang and William L. Woolverton and Jessica E France and Timothy C Gregg and Huw M. L. Davies and Michael A. Nader},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={2003},
  volume={307 1},
  pages={356-66}
}
This study was undertaken to investigate pharmacological variables that influence the reinforcing efficacy of psychostimulants. Rhesus monkeys (n = 9) responded under a within-session, exponentially increasing, progressive ratio schedule of cocaine reinforcement. Doses of cocaine, methylphenidate (MP), cocaine analogs [(+/-)-2beta-propanoyl-3beta-(2-naphthyl)-tropane (WF-23), HD-23; (+/-)-2beta-propanoyl-3beta-(2-isopropenyl)tropane (WF-60), HD-60; and 2beta-propanoyl-3beta-(4-tolyl)-tropane… CONTINUE READING
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