The regulatory subunits of PI3K, p85α and p85β, interact with XBP-1 and increase its nuclear translocation

@article{Park2010TheRS,
  title={The regulatory subunits of PI3K, p85α and p85β, interact with XBP-1 and increase its nuclear translocation},
  author={Sang Won Park and Yingjiang Zhou and Justin Lee and Allen Lu and Cheng Sun and Jason Chung and Kohjiro Ueki and Umut Ozcan},
  journal={Nature Medicine},
  year={2010},
  volume={16},
  pages={429-437}
}
Despite the fact that X-box binding protein-1 (XBP-1) is one of the main regulators of the unfolded protein response (UPR), the modulators of XBP-1 are poorly understood. Here, we show that the regulatory subunits of phosphotidyl inositol 3-kinase (PI3K), p85α (encoded by Pik3r1) and p85β (encoded by Pik3r2) form heterodimers that are disrupted by insulin treatment. This disruption of heterodimerization allows the resulting monomers of p85 to interact with, and increase the nuclear… CONTINUE READING
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