The regulatory role of heat shock protein 70-reactive CD4+ T cells during rat listeriosis.

@article{Kimura1998TheRR,
  title={The regulatory role of heat shock protein 70-reactive CD4+ T cells during rat listeriosis.},
  author={Yutaka Kimura and Kyosuke Yamada and Tohru Sakai and Kenji Mishima and Hitoshi Nishimura and Yoh Matsumoto and Mahavir Singh and Yasunobu Yoshikai},
  journal={International immunology},
  year={1998},
  volume={10 2},
  pages={117-30}
}
Protection against infection with Listeria monocytogenes depends primarily on Listeria-specific T cells. We show here that CD4+ TCR alphabeta+ T cells are capable of recognizing the mycobacterial heat shock protein (HSP) 70, that appears in the peritoneal cavity of F344 rats infected i.p. with L. monocytogenes. The HSP70-reactive CD4+ T cells recognized a peptide comprising 234-252 residues as present in the 70 kDa HSP of Mycobacterium tuberculosis in the context of RT1.B MHC class II molecules… CONTINUE READING
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