The regulatory role of cystatin C in autophagy and neurodegeneration

  title={The regulatory role of cystatin C in autophagy and neurodegeneration},
  author={Tatiana A Korolenko and Alexandra B Shintyapina and Alexander B. Pupyshev and A. A. Akopyan and G. S. Russkikh and Mariya A. Dikovskaya and V. A. Vavilin and E. L. Zavjalov and Maria A Tikhonova and Tamara G. Amstislavskaya},
  journal={Vavilov Journal of Genetics and Breeding},
Autophagy is a dynamic cellular process involved in the turnover of proteins, protein complexes, and organelles through lysosomal degradation. It is particularly important in neurons, which do not have a proliferative option for cellular repair. Autophagy has been shown to be suppressed in the striatum of a transgenic mouse model of Parkinson’s disease. Cystatin C is one of the potent regulators of autophagy. Changes in the expression and secretion of cystatin C in the brain have been shown in… 
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