The regulatory role of Mcl-1 in apoptosis of mouse peritoneal macrophage infected with M . tuberculosis strains that differ in virulence

Abstract

Purpose: Myeloid cell leukaemia-1 (Mcl-1) is a valuable target in tumour treatments. However, several reports have suggested that Mcl-1 may play a role in tuberculosis infection. Therefore, we investigated the function of Mcl-1 in tuberculosis infection and the underlying regulatory mechanism. Methods: Mcl-1-shRNA was used to down-regulate Mcl-1 expression… (More)

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