The regulatory potential of upstream open reading frames in eukaryotic gene expression.

@article{Wethmar2014TheRP,
  title={The regulatory potential of upstream open reading frames in eukaryotic gene expression.},
  author={Klaus Wethmar},
  journal={Wiley interdisciplinary reviews. RNA},
  year={2014},
  volume={5 6},
  pages={765-78}
}
Upstream open reading frames (uORFs) are prevalent cis-regulatory sequence elements in the transcript leader sequences (TLSs) of eukaryotic mRNAs. The majority of uORFs is considered to repress downstream translation by the consumption of functional pre-initiation complexes or by inhibiting unrestrained progression of the ribosome. Under distinct conditions, specific uORF properties or sequential arrangements of uORFs can oppositely confer enhanced translation of the main coding sequence… CONTINUE READING

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RibosomesIs location of biological processGenetic Translation Process
The majority of uORFs is considered to repress downstream translation by the consumption of functional pre - initiation complexes or by inhibiting unrestrained progression of the ribosome .
Ribosome profiling and proteomic studies demonstrated widespread translational activity at AUG- and non - AUG - initiated uORFs in eukaryotic transcriptomes from yeast to human and several reports linked defective uORF - mediated translational control to the development of human diseases .
Ribosome profiling and proteomic studies demonstrated widespread translational activity at AUG- and non - AUG - initiated uORFs in eukaryotic transcriptomes from yeast to human and several reports linked defective uORF - mediated translational control to the development of human diseases .
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