The regulatory link between carbon and nitrogen metabolism in Bacillus subtilis: regulation of the gltAB operon by the catabolite control protein CcpA.

@article{Wacker2003TheRL,
  title={The regulatory link between carbon and nitrogen metabolism in Bacillus subtilis: regulation of the gltAB operon by the catabolite control protein CcpA.},
  author={Ingrid Wacker and Holger Ludwig and Irene Reif and Hans-Matti Blencke and Christian Detsch and J{\"o}rg St{\"u}lke},
  journal={Microbiology},
  year={2003},
  volume={149 Pt 10},
  pages={3001-9}
}
Bacillus subtilis assimilates ammonium by the concerted action of glutamine synthetase and glutamate synthase. The expression of the gltAB operon encoding the latter enzyme is impaired in B. subtilis ccpA mutant strains. CcpA is a pleiotropic transcriptional regulator that is the key factor in the regulation of carbon metabolism. However, in addition to their defect in catabolite repression ccpA mutants are unable to grow on minimal media with glucose and ammonium as the single sources of… CONTINUE READING

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