The regulatory effects of all-trans-retinoic acid on isotype switching: retinoic acid induces IgA switch rearrangement in cooperation with IL-5 and inhibits IgG1 switching.

@article{Tokuyama1999TheRE,
  title={The regulatory effects of all-trans-retinoic acid on isotype switching: retinoic acid induces IgA switch rearrangement in cooperation with IL-5 and inhibits IgG1 switching.},
  author={H. Tokuyama and Y. Tokuyama},
  journal={Cellular immunology},
  year={1999},
  volume={192 1},
  pages={
          41-7
        }
}
All-trans-retinoic acid (RA) can induce germline Calpha transcription in LPS-stimulated murine mu(+)B-cells by a TGF-beta-independent mechanism. In the present study, we examined whether RA can further drive the IgA switching process to Smu-Salpha switch rearrangement by DC-PCR. RA alone could not induce switch rearrangement but required the cooperation of IL-5. RA has another effect on isotype switching; RA strongly inhibits IL-4-dependent IgG1 and IgE production. To analyze the mechanism of… Expand
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References

SHOWING 1-10 OF 16 REFERENCES
Thiols decrease human interleukin (IL) 4 production and IL-4-induced immunoglobulin synthesis
  • 120
  • PDF
Quantitation of immunoglobulin mu-gamma 1 heavy chain switch region recombination by a digestion-circularization polymerase chain reaction method.
  • C. Chu, W. Paul, E. Max
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences of the United States of America
  • 1992
  • 82
  • PDF
...
1
2
...