The regulatory characteristics of yeast fructose-1,6-bisphosphatase confer only a small selective advantage.

@article{Navas1996TheRC,
  title={The regulatory characteristics of yeast fructose-1,6-bisphosphatase confer only a small selective advantage.},
  author={Maria Angeles Navas and Juana M. Gancedo},
  journal={Journal of bacteriology},
  year={1996},
  volume={178 7},
  pages={1809-12}
}
The question of how the loss of regulatory mechanisms for a metabolic enzyme would affect the fitness of the corresponding organism has been addressed. For this, the fructose-1,6-bisphosphatase (FbPase) from Saccharomyces cerevisiae has been taken as a model. Yeast strains in which different controls on FbPase (catabolite repression and inactivation; inhibition by fructose-2,6-bisphosphate and AMP) have been removed have been constructed. These strains express during growth on glucose either… CONTINUE READING

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