The regulatory basis of melanogenic switching.

  title={The regulatory basis of melanogenic switching.},
  author={Leiv \Oyehaug and Erik Plahte and Dag Inge V{\aa}ge and Stig W. Omholt},
  journal={Journal of theoretical biology},
  volume={215 4},
Melanin produced in follicular melanocytes is the major basis for pigmentation of hair and wool in mammals. Two major types of melanin may be synthesized, the black/brown eumelanin and the reddish/yellow pheomelanin. Based on available cell biological evidence and reasonable assumptions, a mathematical model is developed to improve our understanding of melanogenic switching, i.e. the switching between eumelanin and pheomelanin production depending on the extracellular signalling context. In… CONTINUE READING