The regulation of ubiquinone-6 biosynthesis by Saccharomyces cerevisiae.

@article{Sippel1983TheRO,
  title={The regulation of ubiquinone-6 biosynthesis by Saccharomyces cerevisiae.},
  author={C Jeffrey Sippel and R R Goewert and F N Slachman and Robert E. Olson},
  journal={The Journal of biological chemistry},
  year={1983},
  volume={258 2},
  pages={1057-61}
}
Increasing concentrations of glucose (1-5%) in the growth medium depressed ubiquinone-6 biosynthesis in continuously cultured wild type Saccharomyces cerevisiae. In addition, an early intermediate in the pathway of ubiquinone-6 biosynthesis, i.e. 3,4-dihydroxy-5-hexaprenylbenzoate (3,4-DHHB), was found to accumulate. The increase in 3,4-DHHB levels varied inversely with the diminished levels of ubiquinone-6, suggesting that O-methylation of 3,4-DHHB is a regulated step in catabolite repression… CONTINUE READING