The regulation of synaptogenesis during normal development and following activity blockade.

@article{Dahm1991TheRO,
  title={The regulation of synaptogenesis during normal development and following activity blockade.},
  author={Lisa M. Dahm and Lynn T. Landmesser},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={1991},
  volume={11 1},
  pages={238-55}
}
The mature neuromuscular junction is characterized by the tight spatial colocalization of synaptic vesicles and acetylcholine receptor (AChR) clusters. Although a large body of work exists on the interactions between motoneurons and myotubes leading to synaptogenesis in tissue culture, how the neuromuscular junction acquires its highly specialized structure in vivo is not well understood, particularly during the earliest period of synaptogenesis. In this study, the development of the… CONTINUE READING