The regulation of ovine placental steroid 17 alpha-hydroxylase and aromatase by glucocorticoid.

@article{France1988TheRO,
  title={The regulation of ovine placental steroid 17 alpha-hydroxylase and aromatase by glucocorticoid.},
  author={J. T. France and Ronald R Magness and Barbara A Murry and Charles R Rosenfeld and James Ian Mason},
  journal={Molecular endocrinology},
  year={1988},
  volume={2 3},
  pages={193-9}
}
Parturition in the pregnant sheep is preceded by an abrupt alteration in placental steroid metabolism causing a shift from progesterone to estrogen production. This change is believed to be a consequence of the prepartum rise in cortisol in the fetal circulation and involves increases in activities of the enzymes steroid 17 alpha-hydroxylase (cytochrome P-450(17)alpha), steroid C-17,20-lyase, and possibly aromatase. We have investigated the activity levels of aromatase and 17 alpha-hydroxylase… CONTINUE READING

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Parturition in the pregnant sheep is preceded by an abrupt alteration in placental steroid metabolism causing a shift from progesterone to estrogen production .
Parturition in the pregnant sheep is preceded by an abrupt alteration in placental steroid metabolism causing a shift from progesterone to estrogen production .
Parturition in the pregnant sheep is preceded by an abrupt alteration in placental steroid metabolism causing a shift from progesterone to estrogen production .
FetusNo subtypePlacenta
In six animals in labor induced with infusion of dexamethasone into the fetus , placental aromatase activity had a mean value of 14.0 + /-
PlacentaNo subtypeFetus
In six animals in labor induced with infusion of dexamethasone into the fetus , placental aromatase activity had a mean value of 14.0 + /-
Parturition in the pregnant sheep is preceded by an abrupt alteration in placental steroid metabolism causing a shift from progesterone to estrogen production .
Parturition in the pregnant sheep is preceded by an abrupt alteration in placental steroid metabolism causing a shift from progesterone to estrogen production .
Parturition in the pregnant sheep is preceded by an abrupt alteration in placental steroid metabolism causing a shift from progesterone to estrogen production .
Parturition in the pregnant sheep is preceded by an abrupt alteration in placental steroid metabolism causing a shift from progesterone to estrogen production .
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