The regulation of ovarian granulosa cell death by pro- and anti-apoptotic molecules.

@article{MatsudaMinehata2006TheRO,
  title={The regulation of ovarian granulosa cell death by pro- and anti-apoptotic molecules.},
  author={Fuko Matsuda-Minehata and Naoko Inoue and Yasufumi Goto and Noboru Manabe},
  journal={The Journal of reproduction and development},
  year={2006},
  volume={52 6},
  pages={695-705}
}
In the mammalian ovary, follicular development and atresia are closely regulated by cell death and survival-promoting factors, including hormones (gonadotropins) and intraovarian regulators (gonadal steroids, cytokines, and intracellular proteins). Several hundred thousand primordial follicles are present in the mammalian ovary; however, only a limited number of primordial follicles develop to the preovulatory stage and ovulate. The others, more than 99% of follicles, will be eliminated via a… CONTINUE READING
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