The regulation of osteogenesis by ECM rigidity in MC3T3-E1 cells requires MAPK activation.

@article{Khatiwala2007TheRO,
  title={The regulation of osteogenesis by ECM rigidity in MC3T3-E1 cells requires MAPK activation.},
  author={Chirag B. Khatiwala and Shelly R Peyton and Mark Metzke and Andrew J Putnam},
  journal={Journal of cellular physiology},
  year={2007},
  volume={211 3},
  pages={661-72}
}
Once thought to provide only structural support to tissues by acting as a scaffold to which cells bind, it is now widely recognized that the extracellular matrix (ECM) provides instructive signals that dictate cell behavior. Recently we demonstrated that mechanical cues intrinsic to the ECM directly regulate the behavior of pre-osteoblastic MC3T3-E1 cells. We hypothesized that one possible mechanism by which ECM compliance exerts its influence on osteogenesis is by modulating the mitogen… CONTINUE READING