The regulation of luteinizing hormone secretion by estrogen: relationships among negative feedback, surge potential, and male stimulation in juvenile, peripubertal, and adult female mice.

@article{Bronson1981TheRO,
  title={The regulation of luteinizing hormone secretion by estrogen: relationships among negative feedback, surge potential, and male stimulation in juvenile, peripubertal, and adult female mice.},
  author={Franklin H. Bronson},
  journal={Endocrinology},
  year={1981},
  volume={108 2},
  pages={506-16}
}
These experiments queried the potential for developmental change in the positive and negative feedback sensitivities of LH secretion to estradiol. Serum LH levels were compared in juvenile, peripubertal, and adult female mice after ovariectomy and challenge with a variety of 4-day steroid treatments. Since male stimuli accelerate the attainment of puberty in this species, comparisons also were made between age- and weight-matched groups of pre- vs. postpubertal females, obtained by housing them… CONTINUE READING

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