The regulation of interleukin-8 by hypoxia in human macrophages--a potential role in the pathogenesis of the acute respiratory distress syndrome (ARDS).

@article{Hirani2001TheRO,
  title={The regulation of interleukin-8 by hypoxia in human macrophages--a potential role in the pathogenesis of the acute respiratory distress syndrome (ARDS).},
  author={Nikhil Hirani and Frank Antonicelli and Robert M. Strieter and Michael Sean Wiesener and Peter J Ratcliffe and Chris Haslett and Seamas Donnelly},
  journal={Molecular medicine},
  year={2001},
  volume={7 10},
  pages={
          685-97
        }
}
BACKGROUND The acute respiratory distress syndrome (ARDS) represents a form of severe acute inflammatory lung disease. We have previously demonstrated significantly raised interleukin-8 (IL-8) levels in the lungs of at-risk patients that progress to ARDS, and identified the alveolar macrophage as an important source of this chemokine. We wished to extend this study in a well-defined group of patients with major trauma, and to investigate potential mechanisms for rapid intrapulmonary IL-8… CONTINUE READING
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