The regulation of human vascular smooth muscle extracellular matrix protein production by alpha- and beta-adrenoceptor stimulation.

@article{OCallaghan2002TheRO,
  title={The regulation of human vascular smooth muscle extracellular matrix protein production by alpha- and beta-adrenoceptor stimulation.},
  author={Christopher James O'Callaghan and Bryan P. Williams},
  journal={Journal of hypertension},
  year={2002},
  volume={20 2},
  pages={
          287-94
        }
}
OBJECTIVE The sympathetic nervous system (SNS) is commonly activated in hypertension; however, the role of SNS activation in the pathogenesis of cardiovascular structural changes remains poorly defined. In particular, the effect of adrenergic stimulation on extracellular matrix (ECM) protein production by human cardiovascular cells is unknown. The present study thus investigated the direct effect of adrenergic stimulation on ECM protein production by cultured human vascular smooth muscle (VSM… CONTINUE READING
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