The regulation of hematopoietic stem cell and progenitor mobilization by chemokine SDF-1.

@article{Hattori2003TheRO,
  title={The regulation of hematopoietic stem cell and progenitor mobilization by chemokine SDF-1.},
  author={Koichi Hattori and Beate Heissig and Shahin Rafii},
  journal={Leukemia & lymphoma},
  year={2003},
  volume={44 4},
  pages={575-82}
}
The chemokine, stromal derived factor-1 (SDF1) has been shown to modulate the homing of stem cells to its site by mediating chemotaxis. We demontrated overexpression of SDF-1 induced mobilization of cells with stem cell potential (CFU-S, long-term reconstituting cells). Moreover, SDF-1 activated matrix metalloproteinase-9 induced in bone marrow (BM) cells, causing the release soluble Kit-ligand and permitting the transfer of hematopoietic stem cells (HSCs) from a quiescent to a proliferative… CONTINUE READING

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