The regulation of extracellular signal-regulated kinase (ERK) in mammalian cells.

@article{Ramos2008TheRO,
  title={The regulation of extracellular signal-regulated kinase (ERK) in mammalian cells.},
  author={Joe W Ramos},
  journal={The international journal of biochemistry & cell biology},
  year={2008},
  volume={40 12},
  pages={2707-19}
}
The mitogen-activated protein (MAP) kinase extracellular-signal-regulated kinases (ERKs) are activated by diverse mechanisms. These include ligation of receptor tyrosine kinases such as epidermal growth factor (EGF) and cell adhesion receptors such as the integrins. In general, ligand binding of these receptors leads to GTP loading and activation of the… CONTINUE READING