The regulation of epidermal melanogenesis via cAMP and/or PKC signaling pathways: insights for the development of hypopigmenting agents

@article{Lee2013TheRO,
  title={The regulation of epidermal melanogenesis via cAMP and/or PKC signaling pathways: insights for the development of hypopigmenting agents},
  author={Ai-Young Lee and Minsoo Noh},
  journal={Archives of Pharmacal Research},
  year={2013},
  volume={36},
  pages={792-801}
}
Abnormal pigmentation, particularly hyperpigmentation, is major issue of concern for people with colored skin. Several hypopigmenting agents, which exert their action by inhibiting tyrosinase activity and/or transcription, have been used for treatment. However, results have been discouraging. To manage abnormal pigmentation properly, the mechanisms of melanogenesis should be understood. Endogenous and exogenous factors affect melanogenesis via intracellular machineries. cAMP and PKC are… Expand
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References

SHOWING 1-10 OF 96 REFERENCES
Signaling pathways mediating melanogenesis.
Human melanogenesis is stimulated by diacylglycerol.
Cyclic AMP a key messenger in the regulation of skin pigmentation.
Mechanisms of Ultraviolet Light‐Induced Pigmentation
Histamine induces melanogenesis and morphologic changes by protein kinase A activation via H2 receptors in human normal melanocytes.
Modulation of murine melanocyte function in vitro by agouti signal protein
Downregulated melanogenic paracrine cytokine linkages in hypopigmented palmoplantar skin
Bee venom stimulates human melanocyte proliferation, melanogenesis, dendricity and migration
Enzymatic control of pigmentation in mammals
  • V. Hearing, K. Tsukamoto
  • Biology, Medicine
  • FASEB journal : official publication of the Federation of American Societies for Experimental Biology
  • 1991
...
1
2
3
4
5
...