The regulation of epidermal melanogenesis via cAMP and/or PKC signaling pathways: insights for the development of hypopigmenting agents

@article{Lee2013TheRO,
  title={The regulation of epidermal melanogenesis via cAMP and/or PKC signaling pathways: insights for the development of hypopigmenting agents},
  author={Ai-Young Lee and Minsoo Noh},
  journal={Archives of Pharmacal Research},
  year={2013},
  volume={36},
  pages={792-801}
}
Abnormal pigmentation, particularly hyperpigmentation, is major issue of concern for people with colored skin. Several hypopigmenting agents, which exert their action by inhibiting tyrosinase activity and/or transcription, have been used for treatment. However, results have been discouraging. To manage abnormal pigmentation properly, the mechanisms of melanogenesis should be understood. Endogenous and exogenous factors affect melanogenesis via intracellular machineries. cAMP and PKC are… 

Melanogenesis and Melasma Treatment

TLDR
The mechanisms and the signalling pathways involved in skin pigmentation are reviewed and the alteration of melanogenesis that leads to melasma and results in hyperpigmentation is focused on.

Intrinsic and extrinsic regulation of human skin melanogenesis and pigmentation

TLDR
A bioinformatic interaction network gathering the multiple aspects of melanogenesis and skin Pigmentation as a resource to better understand and study skin pigmentation biology is developed.

Angiotensin II stimulates melanogenesis via the protein kinase C pathway.

TLDR
The results suggest that PKC is required for Ang II-induced pigmentation in human melanocytes and that the mechanism involves the PKC pathway and MITF upregulation.

L-765,314 Suppresses Melanin Synthesis by Regulating Tyrosinase Activity

TLDR
The data suggest that L-765,314 could be a potential therapeutic candidate for skin hyperpigmentary disorders and further discovery of selective inhibitors targeting PKC might be a promising strategy for the development of depigmenting agents to treat hyperpIGMENTary disorders.

Effect of ginseng and ginsenosides on melanogenesis and their mechanism of action

  • Kwangmi Kim
  • Biology, Medicine
    Journal of ginseng research
  • 2015

Mechanisms and Therapeutic Prospects of Peptides in Skin Pigmentation

TLDR
A novel platform to modulate skin pigmentation is the use of oligopeptides designed with affinity towards the active sites in molecules of the melanogenesis pathway, which can be designed to increase activity, prolong in vivo stability, promote penetration into cells and minimize side effects when compared to the molecules they mimic, or other drugs.

Inhibitory effects of p-alkylaminophenol on melanogenesis.

Sesamol decreases melanin biosynthesis in melanocyte cells and zebrafish: Possible involvement of MITF via the intracellular cAMP and p38/JNK signalling pathways

TLDR
It is suggested that sesamol represents a new skin‐whitening agent for use in cosmetics because it strongly inhibits melanin biosynthesis and the activity of intracellular tyrosinase.

Fraxinol Stimulates Melanogenesis in B16F10 Mouse Melanoma Cells through CREB/MITF Signaling

TLDR
The results suggest that fraxinol enhances melanogenesis via a protein kinase A-mediated mechanism, which may be useful for developing potent melanogenesis stimulators.

References

SHOWING 1-10 OF 96 REFERENCES

Signaling pathways mediating melanogenesis.

TLDR
Recent progress in identifying signal transduction pathways that mediate melanogenesis is reviewed, which is the key physiologic defense against sun-induced injuries such as sunburn, photocarcinogenesis and photoaging.

Human melanogenesis is stimulated by diacylglycerol.

TLDR
A diacylglycerol analogue 1-oleoyl-2-acetyl- glycerol (OAG) 25-100 microns strikingly increased the melanin content of cultured human melanocytes in a dose dependent manner without altering growth rate.

Cyclic AMP a key messenger in the regulation of skin pigmentation.

TLDR
It appears that melanogenic gene expression is controlled by a complex network of regulation involving other transcription factors such as Brn2, TBX2, PAX3 and SOX10, which would finally allow a fine tuning of melanocyte differentiation leading to melanin synthesis.

Mechanisms of Ultraviolet Light‐Induced Pigmentation

TLDR
Overall, ultraviolet-induced melanogenesis may be one part of a eukaryotic SOS response to damaging ultraviolet irradiation that has evolved over time to provide a protective tan in skin at risk of further injury from sun exposure.

Histamine induces melanogenesis and morphologic changes by protein kinase A activation via H2 receptors in human normal melanocytes.

TLDR
It is shown here that histamine induces melanogenesis of human cultured melanocytes by protein kinase A activation via H2 receptors, and cAMP accumulation and subsequent protein kinases A activation plays a critical role in histamine-induced melanogenesis.

Withania somnifera extract attenuates stem cell factor-stimulated pigmentation in human epidermal equivalents through interruption of ERK phosphorylation within melanocytes

TLDR
The sum of these findings indicates that WSE attenuates SCF-stimulated pigmentation by preferentially interrupting ERK phosphorylation within melanocytes and can serve as a therapeutic tool forSCF-associated hyperpigmentary disorders.

Modulation of murine melanocyte function in vitro by agouti signal protein

TLDR
It is demonstrated that eumelanogenic melanocytes can be induced in culture by ASP to exhibit features characteristic of pheomelanogenesis in vivo, consistent with the hypothesis that the effects of ASP on melanocytes are not mediated solely by inhibition of MSH binding to its receptor.

Downregulated melanogenic paracrine cytokine linkages in hypopigmented palmoplantar skin

TLDR
Findings suggest the possibility that downregulation of ET‐1/SCF/receptor linkages is also associated with the decreased function of melanocytes in PP skin.

Enzymatic control of pigmentation in mammals

  • V. HearingK. Tsukamoto
  • Biology
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology
  • 1991
TLDR
Future research should provide a greater understanding of the enzymatic interactions, processing, and tissue specificity that are important to pigmentation in mammals.

Bee venom stimulates human melanocyte proliferation, melanogenesis, dendricity and migration

TLDR
It is demonstrated that BV may have an effect on the melanocyte proliferation, melanogenesis, dendricity and migration through complex signaling pathways in vitro, responsible for the pigmentation, and suggests a possibility that Bv may be developed as a therapeutic drug for inducing repigmentation in vitiligo skin.
...