The regulation of embryo implantation and endometrial decidualization by progesterone receptor signaling
@article{Large2012TheRO, title={The regulation of embryo implantation and endometrial decidualization by progesterone receptor signaling}, author={Michael J. Large and Francesco J. DeMayo}, journal={Molecular and Cellular Endocrinology}, year={2012}, volume={358}, pages={155-165} }
Figures from this paper
120 Citations
Hormone dependent uterine epithelial-stromal communication for pregnancy support.
- Biology, MedicinePlacenta
- 2017
Regulatory mechanisms of endometrial decidualization and pregnancy-related diseases.
- Medicine, BiologyActa biochimica et biophysica Sinica
- 2019
These crucial elements in decidualization are summarized and discussed and a better comprehension of these issues should help to improve the prediction of pregnancy outcomes and the use of appropriate intervention.
Promoting Roles of Embryonic Signals in Embryo Implantation and Placentation in Cooperation with Endocrine and Immune Systems
- Biology, MedicineInternational journal of molecular sciences
- 2020
Further clarification of the immune control mechanisms by embryonic signals, such as human chorionic gonadotropin, pre-implantation factor, zona pellucida degradation products, and laeverin, will aid in the further development of immunotherapy to minimize implantation failure in the future.
Homeostasis imbalance in the endometrium of women with implantation defects: the role of estrogen and progesterone.
- Biology, MedicineSeminars in reproductive medicine
- 2014
It is argued that estrogen action is a prime target for future therapeutic solutions to endometriosis and implantation failure that result from this chronic, inflammatory disease.
Progesterone and Estrogen Signaling in the Endometrium: What Goes Wrong in Endometriosis?
- Biology, MedicineInternational journal of molecular sciences
- 2019
Understanding how these mechanisms contribute to the pelvic pain and infertility associated with endometriosis will open new avenues of targeted medical therapies to give relief to the millions of women suffering its effects.
Cyclic decidualization of the human endometrium in reproductive health and failure.
- Biology, MedicineEndocrine reviews
- 2014
The endocrine, paracrine, and autocrine cues that tightly govern this differentiation process are reviewed and how disorders that subvert the programming, initiation, or progression of decidualization compromise reproductive health and predispose for pregnancy failure is discussed.
Molecular characterization of the endometrium as a fertility-determining factor
- Biology, Medicine
- 2020
The primary function of the endometrium is to provide an immuno-privileged site for embryo implantation and to provide a nurturing environment for the fetus during pregnancy.
Molecular Mechanisms Regulating Embryo Implantation in Mammals
- Biology, Medicine
- 2015
This review discusses in the understanding recent advances of the molecular events during implantation, especially focusing on the roles of estrogen and P4 signaling, and offers thoughts on the as yet unelucidated processes in implantation to guide and stimulate further research.
References
SHOWING 1-10 OF 161 REFERENCES
Epithelial-stromal interaction and progesterone receptors in the mouse uterus.
- Biology, MedicineSeminars in reproductive medicine
- 2010
Evidence increasingly demonstrates that the progesterone receptor (PR) is a major mediator of epithelial-stromal cross talk and events leading to the disruption of this communication can lead to P4 resistance in the uterus.
Control of Uterine Cell Proliferation and Differentiation by C/EBPb: Functional Implications for Establishment of Early Pregnancy
- Biology, MedicineCell cycle
- 2006
It is postulated that C/EBPb controls the expression of critical molecules that regulate proliferation and function of epithelial and stromal cells in the female reproductive tract during the establishment of early pregnancy.
Decidualization of the human endometrium: mechanisms, functions, and clinical perspectives.
- Biology, MedicineSeminars in reproductive medicine
- 2007
In humans, decidualization of the stromal compartment occurs in the mid-luteal phase of the menstrual cycle, independently of pregnancy, raising the possibility that biochemical analysis of timed endometrial biopsy samples taken in a nonconception cycle could be informative of subsequent pregnancy outcome.
The Antiproliferative Action of Progesterone in Uterine Epithelium Is Mediated by Hand2
- Biology, MedicineScience
- 2011
This study reveals that progesterone-induced expression of the basic helix-loop-helix transcription factor Hand2 in the uterine stroma suppresses the production of several fibroblast growth factors that act as paracrine mediators of mitogenic effects of estrogen on the epithelium.
Identification of Indian hedgehog as a progesterone-responsive gene in the murine uterus.
- BiologyMolecular endocrinology
- 2002
It is suggested that Ihh is regulated by P4, and the Ihh signaling axis may play a role in the preparation of the uterus for implantation during the periimplantation period.
C/EBPbeta is a critical mediator of steroid hormone-regulated cell proliferation and differentiation in the uterine epithelium and stroma.
- Biology, MedicineProceedings of the National Academy of Sciences of the United States of America
- 2006
Three studies established that C/EBPbeta is a key mediator of steroid responsiveness of the epithelium and stroma in the mouse uterus and defects in steroid-hormone-dependent responses in the uteri of these mice are revealed.
COUP-TFII Mediates Progesterone Regulation of Uterine Implantation by Controlling ER Activity
- Biology, MedicinePLoS Genetics
- 2007
A novel genetic pathway in which BMP2 lies downstream of COUP-TFII is identified, which provides a new signaling paradigm for steroid hormone regulation in female reproductive biology, with attendant implications for furthering the understanding of the molecular mechanisms that underlie dysregulation of hormonal signaling in such human reproductive disorders as endometriosis and endometrial cancer.
Hoxa-10 regulates uterine stromal cell responsiveness to progesterone during implantation and decidualization in the mouse.
- Biology, MedicineMolecular endocrinology
- 1999
The results suggest that Hoxa-10 mutation causes specific stromal cell defects that can lead to implantation and decidualization defects apparently without perturbing epithelial cell functions.
Amphiregulin is an implantation-specific and progesterone-regulated gene in the mouse uterus.
- Biology, MedicineMolecular endocrinology
- 1995
The cloned murine amphiregulin gene, a newly discovered member of the epidermal growth factor family, is cloned and demonstrated that its expression is implantation-specific and P4-regulated in the mouse uterus, a first report of a P 4-regulated uterine epithelial cell growth factor that is associated with epithel cell differentiation during implantation.
Blastocyst implantation depends on maternal expression of leukaemia inhibitory factor
- BiologyNature
- 1992
It is reported that transient expression of LIF in mice is essential for implantation, and females lacking a functional LIF gene are fertile, but their blastocysts fail to implant and do not develop.