The regulation of eIF-2 function protein synthesis initiation.

Abstract

The regulation of eIF-2 activity during protein synthesis initiation has been postulated to involve phosphorylation/dephosphorylation mechanisms and/or the participation of ancillary protein factors. Both mechanisms would affect directly the binding of initiator methionyl-tRNAi by eIF-2. Recent data concerning the phosphorylation state of eIF-2 in hemin… (More)

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