The regulation of cell motility and chemotaxis by phospholipid signaling.

@article{Klsch2008TheRO,
  title={The regulation of cell motility and chemotaxis by phospholipid signaling.},
  author={Verena K{\"o}lsch and Pascale G. Charest and Richard A. Firtel},
  journal={Journal of cell science},
  year={2008},
  volume={121 Pt 5},
  pages={551-9}
}
Phosphoinositide 3-kinase (PI3K), PTEN and localized phosphatidylinositol (3,4,5)-trisphosphate [PtdIns(3,4,5)P3] play key roles in chemotaxis, regulating cell motility by controlling the actin cytoskeleton in Dictyostelium and mammalian cells. PtdIns(3,4,5)P3, produced by PI3K, acts via diverse downstream signaling components, including the GTPase Rac, Arf-GTPases and the kinase Akt (PKB). It has become increasingly apparent, however, that chemotaxis results from an interplay between the PI3K… CONTINUE READING

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