The regulation of aldosterone synthase expression

  title={The regulation of aldosterone synthase expression},
  author={M. H. Bassett and P. White and W. Rainey},
  journal={Molecular and Cellular Endocrinology},
  • M. H. Bassett, P. White, W. Rainey
  • Published 2004
  • Biology, Medicine
  • Molecular and Cellular Endocrinology
  • Aldosterone, the primary human mineralocorticoid, is a major regulator of intravascular volume and blood pressure. The capacity of the adrenal gland to produce aldosterone is controlled, in large part, by the regulated transcription of CYP11B2, the gene encoding aldosterone synthase. Aldosterone synthase is responsible for the conversion of 11-deoxycorticosterone to aldosterone and is expressed only within the zona glomerulosa of the adrenal cortex. The development of new systems for in vitro… CONTINUE READING
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