The regulation of actin remodeling during T-cell-APC conjugate formation.

  title={The regulation of actin remodeling during T-cell-APC conjugate formation.},
  author={Judy L. Cannon and Janis K Burkhardt},
  journal={Immunological reviews},
The T-cell cytoskeleton is intimately involved in determining the efficiency and fidelity of the immune response. During T-cell interactions with antigen-presenting cells (APCs), dynamic remodeling of the actin cytoskeleton is particularly important for stabilizing long-lived integrin-dependent adhesive interactions. In addition, actin remodeling is important for facilitating the sustained signaling required for full T-cell activation. Although the relationship between T-cell signaling and… CONTINUE READING
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