The regulation of TNFα production after heat and endotoxin stimulation is dependent on Annexin-A1 and HSP70

@article{Nair2015TheRO,
  title={The regulation of TNFα production after heat and endotoxin stimulation is dependent on Annexin-A1 and HSP70},
  author={Sunitha Nair and Suruchi Arora and Jyue Yuan Lim and Lay Hoon Lee and Lina H. K. Lim},
  journal={Cell Stress and Chaperones},
  year={2015},
  volume={20},
  pages={583-593}
}
Febrile temperatures can induce stress responses which protect cells from damage and can reduce inflammation during infections and sepsis. However, the mechanisms behind the protective functions of heat in response to the bacterial endotoxin LPS are unclear. We have recently shown that Annexin-1 (ANXA1)-deficient macrophages exhibited higher TNFα levels after LPS stimulation. Moreover, we have previously reported that ANXA1 can function as a stress protein. Therefore in this study, we… CONTINUE READING
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