The regulation of OLFM4 expression in myeloid precursor cells relies on NF-kappaB transcription factor.

@article{Chin2008TheRO,
  title={The regulation of OLFM4 expression in myeloid precursor cells relies on NF-kappaB transcription factor.},
  author={Kyung L Chin and Wulin Aerbajinai and Jiangqiong Zhu and L R Drew and Ling Chen and Wenli Liu and Griffin P. Rodgers},
  journal={British journal of haematology},
  year={2008},
  volume={143 3},
  pages={421-32}
}
The human olfactomedin 4 gene (OLFM4, also known as hGC-1, GW112) is thought to be a useful marker for early myeloid development. To understand the molecular mechanisms underlying granulocyte colony-stimulating factor (G-CSF)-stimulated OLFM4 expression, we characterized the promoter region of OLFM4. The 35-bp region (-101 to -66) of the proximal promoter regulated reporter gene expression, and mutation of the nuclear factor (NF)-kappaB binding site within the promoter abolished the binding of… CONTINUE READING