The regulation of MDM2 by multisite phosphorylation--opportunities for molecular-based intervention to target tumours?

@article{Meek2010TheRO,
  title={The regulation of MDM2 by multisite phosphorylation--opportunities for molecular-based intervention to target tumours?},
  author={D. W. 5303 Meek and Ted R. Hupp},
  journal={Seminars in cancer biology},
  year={2010},
  volume={20 1},
  pages={19-28}
}
The p53 tumour suppressor is a tightly controlled transcription factor that coordinates a broad programme of gene expression in response to various cellular stresses leading to the outcomes of growth arrest, senescence, or apoptosis. MDM2 is an E3 ubiquitin ligase that plays a key role in maintaining p53 at critical physiological levels by targeting it for proteasome-mediated degradation. Expression of the MDM2 gene is p53-dependent and thus p53 and MDM2 operate within a negative feedback loop… CONTINUE READING