The regulation of Hox gene expression during animal development.

@article{Mallo2013TheRO,
  title={The regulation of Hox gene expression during animal development.},
  author={Moises Mallo and Claudio R Alonso},
  journal={Development},
  year={2013},
  volume={140 19},
  pages={3951-63}
}
Hox genes encode a family of transcriptional regulators that elicit distinct developmental programmes along the head-to-tail axis of animals. The specific regional functions of individual Hox genes largely reflect their restricted expression patterns, the disruption of which can lead to developmental defects and disease. Here, we examine the spectrum of molecular mechanisms controlling Hox gene expression in model vertebrates and invertebrates and find that a diverse range of mechanisms… CONTINUE READING
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